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By W. N. Aldridge (eds.)

ISBN-10: 1349010855

ISBN-13: 9781349010851

ISBN-10: 1349010871

ISBN-13: 9781349010875

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It was found that on intravenous injection of soman into these rats the body temperature begins to fall before the tail responds (Fig. 2). The tail response is rather variable and may be very weak in some animals. ;38 36 34 oc 30 28 26 24 1' 0 1 2 nme(hl FIG. 2. g/kg) on the body temperature (upper line) and the tail temperature (lower line). Injection at arrow through a cannula inserted into the jugular vein on the previous day. It was demonstrated earlier (Fig. 1) that atropine markedly reduces the hypothermia caused by soman.

1969). Biochem. , 18, 1011, 1021 CoLLINS, G. G. , YoUDIM, M. B. H. & SANDLER, M. (1968). , 1, 215 CoLLINS, G. G. , WILLIAMS, E. D. & YoumM, M. B. H. (1970). , SHAW, D. , HERZBERG, B. & Muoos, R. (1970). Lancet, 2, 1178 CREASEY, N. H. (1956). Biochem. , 64, 178 DAVISON, A. N. (1957). Biochem. , 67, 316 ERWIN, V. G. & HELLERMAN, L. (1967). J. bioi. , KLOEPFER, H. G. & YASUNOBU, K. T. (1969). Arch. Biochem. , 132, 16 GORKIN, V. Z. (1966). Pharmac. , 18, 115 HALL, D. W. , LoGAN, B. W. & PARSONS, G.

M), imidazole-HCI buffer (pH 7·2; 0·05 M), 2-mercaptoethanol (0·001 M), ATP (0·005 M), MgCb (0·01 M) and the following; • - • · L-methionine-R-sulphoximine (1·0 mM); /::;-/::;, L-methionine-R-sulphoximine (5·0 mM); e-e, L-methionine-SR-sulphoximine (1·0 mM); 0-0, L-methionine-S-sulphoximine (0·5 mM); final volume, 0·05 mi. Ll) were removed and enzyme activity was determined in the standard 1 ml y-glutamyl hydroxamate assay system. ) 56 A. Meister, R. A. Ronzio, W. B. Rowe, J. D. Gass, & S. L. N.

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A Symposium on Mechanisms of Toxicity by W. N. Aldridge (eds.)

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