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By I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins

ISBN-10: 0123525519

ISBN-13: 9780123525512

  • ''...the quantity surely succeeds total as an in-depth survey of either the biology and the biochemistry of a ubiquitous and astonishingly various family members of very complicated enzymes. each workforce with an curiosity in those proteins may still personal a copy.'' -CELL (July 2003) ''The editors of ABC Proteins: From micro organism to Man have valiantly tried to surround during this quantity the whole scope of analysis on those proteins, from atomic-resolution constitution to human genetic ailments, and from Escherichia coli to Homo sapiens and Arabidopsis thaliana... What the ebook makes seen is that almost all ABC proteins are membrane localized, ATP established, basic energetic transporters...In addition to advances in our realizing of ABC transporter constitution, numerous chapters within the ebook additionally describe development that has been made in elcuidating the mechanisms of delivery. the quantity certainly succeeds total as an in-depth survey of either the biology and the biochemistry of a ubiquitous and astoundingly various relations of very advanced enzymes. each team with an curiosity in those proteins may still personal a duplicate. eventually, this ebook makes a resounding case that many laboratories that will not but suspect it is going to quickly have a way more abiding curiosity in ABC proteins.'' ''...well prepared and integrated superbly transparent colour photographs and figures.'' -E STREAMS (July 2003)

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There are, however, some exceptions. The genome of Thermotoga maritima has a very high content of ABC systems compared with that of species of similar genome size. This is due to the extensive amplification of operons encoding ABC systems putatively involved in the uptake of oligosaccharides (11 systems) and oligopeptides (12 systems). On the other hand, the genome of M. 4 Mb) has only 38 systems. This number is significantly lower than that found in E. 6 Mb, 78 systems) or in B. 2 Mb, 84 systems).

2000) Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290, 1771–1775. , Distler, J. and Piepersberg, W. 0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR. Mol. Gen. Genet. 250, 775–784. , Lebleu, B. and Salehzada, T. (1995) Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J. Biol. Chem. 270, 13308–13317. , Le Roy, F. and Salehzada, T. (2000) The 2Ј-5Ј oligoadenylate/ RNase L/RNase L inhibitor pathway regulates both MyoD mRNA stability and muscle cell differentiation.

409, 247–252. , et al. (1998) Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. J. Biol. Chem. 273, 32167–32175. , Wolfger, H. and Kuchler, K. (1999) Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim. Biophys. Acta 1461, 217–236. P. and Trowsdale, J. (1992) DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. J. Mol. Biol. 228, 433–441.

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ABC Proteins. From Bacteria to Man by I Barry Holland, Susan P. C. Cole, Karl Kuchler, Christopher F. Higgins

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